Mission Bay is a prime-tier Class A submarket of San Francisco with average asking rent around $78/sqft/yr.
Life-sciences and tech campus belt south of SOMA. · Tier: prime · Avg rent: $78/sqft/yr
Mission Bay is San Francisco's purpose-built life-sciences and tech campus district, anchored by UCSF and Chase Center. Lab + office hybrids dominate.
Life sciences, biotech, healthcare technology.
20–40,000 sqft floor plates available across newer Class A stock.
T Third Street light rail, Caltrain 4th & King.
Multi-modal transit with high commute capture from the city's professional catchment.
Chase Center, UCSF Medical Center.
Mission Bay is one of 6 Class A submarkets we cover in San Francisco, classified as prime tier with an average asking rent around $78/sqft/yr. Compared with the broader San Francisco Class A stock, Mission Bay typically attracts Life sciences, biotech, healthcare technology and competes most directly with the city's other prime submarkets on building specification, transit access, and amenitisation.
Adjacent submarkets to study alongside Mission Bay: Transbay, Financial District, Mission Bay & SoMa, Jackson Square. The full San Francisco submarket atlas is at /cities/san-francisco.
For an institutional Class A occupier evaluating Mission Bay, the highest-leverage analyses to commission next are the rent benchmark, the concession-package comparable, and the ESG performance baseline. Class A Atlas covers each as a dedicated topic page for this submarket:
Terminology specific to San Francisco Class A leasing and to the prime tier: Class A, Trophy asset, Effective rent, Concession package, TI allowance, Submarket tier.
Reviewed by Miriam Hollander — Lead market analyst. Last updated 2026-04-15. See our methodology and editorial standards.