Lake Nona is a trophy-tier Class A submarket of Orlando with average asking rent around $42/sqft/yr.
Master-planned life-sciences and healthcare frontier. · Tier: trophy · Avg rent: $42/sqft/yr
Lake Nona Medical City is the master-planned life-sciences, healthcare, and education district — AdventHealth, Nemours Children's Hospital, USTA national campus, KPMG Lakehouse, UCF College of Medicine.
Healthcare (AdventHealth, Nemours), life sciences, education, simulation/training.
15–40,000 sqft floor plates available across newer Class A stock; 9'+ slab-to-slab and modern MEP common.
LYNX bus; SunRail extension planned.
Multi-modal transit captures the metro's principal professional catchment.
Lake Nona Town Center, USTA campus, KPMG Lakehouse.
Lake Nona is one of 5 Class A submarkets we cover in Orlando, classified as trophy tier with an average asking rent around $42/sqft/yr. Compared with the broader Orlando Class A stock, Lake Nona typically attracts Healthcare (AdventHealth, Nemours), life sciences, education, simulation/training and competes most directly with the city's other trophy submarkets on building specification, transit access, and amenitisation.
Adjacent submarkets to study alongside Lake Nona: Downtown, Maitland / Altamonte Springs, Lake Mary / Heathrow, I-Drive / Tourism Corridor. The full Orlando submarket atlas is at /cities/orlando.
For an institutional Class A occupier evaluating Lake Nona, the highest-leverage analyses to commission next are the rent benchmark, the concession-package comparable, and the ESG performance baseline. Class A Atlas covers each as a dedicated topic page for this submarket:
Terminology specific to Orlando Class A leasing and to the trophy tier: Class A, Trophy asset, Effective rent, Concession package, TI allowance, Submarket tier.
Reviewed by Class A Atlas Editorial Desk — House byline · global editorial team. Last updated 2026-04-15. See our methodology and editorial standards.