San Diego Class A office rents around 56 USD/sqft/yr (56 USD), with 18.4% vacancy and 12 months of typical rent-free on a 10-year term.
UTC / Torrey Pines is the deepest life sciences and biotech submarket in California.
Defense and intelligence tenancy underwrites long-duration leases (federal anchors).
Downtown trophy product is comparatively soft — Class A trades at $48-$54/sqft.
Naval and Marine adjacency drives long-term defense tenant demand.
San Diego Class A Office Market
Life sciences capital of the West Coast with deep biotech and defense tenancy.
TL;DR
UTC / Torrey Pines is the deepest life sciences and biotech submarket in California.
Defense and intelligence tenancy underwrites long-duration leases (federal anchors).
Downtown trophy product is comparatively soft — Class A trades at $48-$54/sqft.
Naval and Marine adjacency drives long-term defense tenant demand.
Overview
San Diego's Class A market is structurally anchored by the largest life sciences cluster on the West Coast, deep defense and intelligence tenancy, and a growing tech base. UTC / Torrey Pines life sciences submarket is among the tightest in the US.
Market snapshot
Class A rent
56 USD/sqft/yr (56 USD)
Vacancy
18.4%
Typical lease length
10 years
Typical rent-free
12 months
Composite of Q1 2026 broker market reports for San Diego.
Lease norms
Modified-gross structures with opex pass-throughs. 10-12 year terms common for life sciences. Free rent of 10-14 months and TI of $100-$160/sqft typical on a 10-year Class A deal; lab fitouts run materially higher.
Transit & access
MTS trolley (Blue, Green, Orange, UC San Diego Blue Line extension to UTC). COASTER and Sprinter commuter rail. Heavy car dependency outside the urban core.
Tax
21% federal plus 8.84% California corporate franchise tax for an effective rate near 27.9%. California property tax (Prop 13) base is set at acquisition; meaningful for long-term ownership.
Talent
Deep life sciences, biotech, defense, and intelligence talent. UCSD and the Salk / Scripps research cluster anchor. Deep naval and Marine veteran talent pool.
Notable Class A buildings
One La Jolla Center · UTC — UTC's first Class A high-rise; long-time Qualcomm anchor.
The Campus at Horton · Downtown — Major reposition.
Symphony Towers · Downtown — San Diego's tallest tower for over three decades.
Alexandria Point Loma · Sorrento Mesa — Life sciences trophy.
Torrey View · Torrey Pines — Life sciences campus.
Direct vacancy in life sciences product is sub-7% as of Q1 2026. Lab-ready inventory is structurally tight.
What is the defense tenancy concentration?
Material. Northrop Grumman, General Atomics, Booz Allen, and a deep cluster of defense contractors anchor Class A demand around Sorrento Mesa and Kearny Mesa.
Is downtown San Diego recovering?
Slowly. The Campus at Horton reposition is the single largest downtown leasing event of the cycle. Broader recovery requires sustained demand diversification.